[1] Penarol 3-0 River Plate [2] 2021-05-07 00:30
Stadium: Stade Campeon del Siglo Round: 3
Referee: Carlos Anibal Orbe Ruiz Home Manager: Jose Mauricio Larriera Away Manager: Ariel Galeano
Home History
| Copa Sudamericana | 2021/04/29 22:15 | Corinthians v Penarol | W | 0-2 |
| Copa Sudamericana | 2021/04/23 00:30 | Penarol v Sport Huancayo | W | 5-1 |
| Copa Sudamericana | 2021/04/14 00:30 | Penarol v Cerro Largo | W | 4-1 |
| Copa Sudamericana | 2021/04/07 00:30 | Cerro Largo v Penarol | D | 2-2 |
| Première division, Playoffs | 2021/03/30 00:15 | Penarol v Atletico Fenix Montevideo | W | 3-1 |
| Première division, Playoffs | 2021/03/25 19:00 | Club Atlético Progreso v Penarol | W | 0-2 |
| Première division, Playoffs | 2021/03/20 22:00 | Penarol v Plaza Colonia | L | 1-3 |
| Première division, Playoffs | 2021/03/15 00:45 | Torque v Penarol | W | 1-2 |
Away History
| Paraguay - Division Profesional | 2021/05/03 23:00 | River Plate v Libertad Asuncion | L | 1-3 |
| Copa Sudamericana | 2021/04/29 22:15 | Sport Huancayo v River Plate | W | 1-2 |
| Paraguay - Division Profesional | 2021/04/26 22:15 | Sportivo Luqueno v River Plate | D | 2-2 |
| Copa Sudamericana | 2021/04/23 00:30 | River Plate v Corinthians | D | 0-0 |
| Paraguay - Division Profesional | 2021/04/18 00:00 | River Plate v Sol de America | L | 0-2 |
| Paraguay - Division Profesional | 2021/04/12 23:00 | Guarani Asuncion v River Plate | L | 2-0 |
| Copa Sudamericana | 2021/04/08 22:15 | River Plate v Guairena | W | 4-2 |
| Paraguay - Division Profesional | 2021/04/01 22:15 | River Plate v 12 de Octubre | L | 0-2 |